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Exposure towards the glucuronide metabolite is 35 to 40 situations greater than exposure on the guardian drug. In vitro info counsel that hydromorphone in clinically related concentrations has minimal prospective to inhibit the action of human hepatic CYP450 enzymes which include CYP1A2, 2C9, 2C19, 2D6, 3A4, and 4A11.When the reaction to opioid ant